Dr. Ngugi Mathew Piero

Medical Biochemistry Students


PhD Students


CAROLYN WANJIRA MURUTHI
PhD ( Medical Biochemistry )
Areas of Interest: Medical Biochemistry, Molecular Oncology and Natural Product Chemistry
Email:mwcarolyn@gmail.com

Project Title: In vitro antiproliferative and antioxidant activities of Pappea capensis and Carissa edulis

Project Summary

The study focuses on establishing the bio-active compounds present in Carissa edulis and Pappea capensis extracts, their ability in inhibiting proliferation of selected cancer cell lines and amelioration of oxidative stress. Their possible mode of action through upregulation of apoptotic genes are also explored.


DANIEL MUTHEE GAICHU
PhD ( Medical Biochemistry )
Areas of Interest: Drug development and Drug Discovery, Pharmacognosy and Phytomedicine.
Email:danielgaichu2016@gmail.com

Project Title: Phytochemical Profile, Cardioprotective Effects and Safety of Aqueous Leaf Extracts of Ximenia americana and Pappeacapensis

Project Summary

The study aims atidentification and quantification of phytochemicals present inthe leaf extracts of Ximenia americana and Pappea capensis,as well as in vivo cardio-curative and cardio-protective potential of the two extracts. The antioxidant potential of the two extracts is also being explored as a mechanism of their action. The study also looks at the safety profiles of both plant extractsin vivo


GICHINA WILSON KAMAU
PhD ( Medical Biochemistry )
Areas of Interest: Medical Biochemistry and Natural Product Chemistry
Email:gichinakamaugichina@gmail.com

Project Title: Ameliorative and Antioxidant Effects of Leaf Extract of Ipomea Batatasfollowing Lead, Cadmium And Arsenic-Induced Toxicity in Mice

Project Summary

The study will focus on ameliorating heavy metal toxicity using plant extracts to complement the current conventional methods in use.


NGAI DAVID NYAGA (MSc)
PhD ( Medical Biochemistry )
Areas of Interest: No areas of interest given
Email:konjingai@gmail.com

Project Title: Cognitive enhancing and Antioxidant Effects of Extracts of Prunus africana in Scopolamine-Treated Mice.

Project Summary

In the current study, the effects of crude methanolic leaf and stem bark extracts of Prunus africana on cognitive abilities and oxidative stress in scopolamine treated mice was investigated. The passive avoidance and Morris water maze tasks were used to determine the ameliorating effects of the extracts in Alzheimers mice models while cholinesterase activity was evaluated to assess the extract’s inhibitory effects on the enzyme. Antioxidant activity is a vital property of plant extracts that are used with great success to manage lifestyle diseases like AD since such diseases are usually accompanied by oxidative stress. The enzymatic antioxidant activity of the extracts was determined through the assessment of the activities of glutathione reductase, glutathione peroxidase, catalase and superoxide dismutase. The non enzymatic antioxidants were assessed by determining the levels of reduced glutathione in the brain homogenates of the extracts treated mice.

 

The phytochemicals present in the extract will be determined in an effort to detect and quantify medicinal compounds such as anthroquinones that have anti-cholinesterase activity, quinoxalines that have anti-protein kinase activity and phenothiazines which are said to have anti-psychotic activity among others. The extracts administration was by the oral route. Scopolamine hydrobromide (5mg/kg bwt) was administered intraperitoneally daily throughout each study period. The drug substance, scopolamine, is known to lower the transcription of brain derived neurotrophic factor which is responsible for memory elasticity and development and it also interferes with functioning of acetylcholine receptors. The compounds that reverse these scopolamine induced deficits in mice are considered potential medicines for cognitive impairments in man due to the common phylogenetic relationship between man and rodents as omnivorous mammals.


ELIAKIM MBAKA
PhD ( Medical Biochemistry )
Areas of Interest: Medical Biochemistry, Phytomedicine, Drug Develpment, Pharmacoogy, Green Chemistry, Nanotechnology and Bioinformatics
Email:kimeliakim2005@gmail.com

Project Title: In Vivo Hepatoprotective, Nephroprotective and Antioxidant Activities of Selected Kenyan Medicinal Plants

Project Summary

Herbs are the primary source of the bioactive compounds that are very vital in the management of various ailments. Extracts from Kigelia africana, Terminalia brownii and Acacia hockii widely have been used as antioxidant, anti-jaundice, anti-malarial, anti-hemolysis and many more. Therefore, this study will provide the basis on which K. africana, T. brownii and A. hockii as a plant-derived source of a drug against hepatotoxicity, nephrotoxicity, other oxidative stress-related disorders. Further, the study will offer information on identification, separation and quantification of bioactive compounds from the experimental extracts which will be used in the treatment of symptomatic complications of liver and kidney damage viz; cardiovascular diseases, obesity, diabetes activity.


MARTIN MUGENDI NJAGI
PhD ( Medical Biochemistry )
Areas of Interest: Medical Biochemistry and Drug Discovery, Biotechnology, and Environmental and Occupational Safety and Health
Email:mmugendin@gmail.com

Project Title: In Vivo Anti-Obesity and Cardio-Protective Properties of Aqueous and Hexane Extracts of Momordica Charantiaand Solanum Incanum

Project Summary

My current research is focused on assessing the effectiveness of Momordica charantia andSolanum incanumextracts in anti-obesity and cardio-protective activities. The plants extracts have been used variously in traditional settings for similar functions. However, no empirical scientific data exist to confirm or validate these uses.


PHILLIP EINSTEIN OGOLA
PhD ( Medical Biochemistry )
Areas of Interest: Environmental Radioactivity Monitoring, Radiation Protection, Exposure Assessment, Environmental Epidemiology, Biochemical Toxicology and Alternative Medicine.
Email:phileinst@gmail.com

Project Title: Determination of Background Ionizing Radiation in Human Habitat and Food: A Potential Cause of Cancer Incidences in Kenya.

Project Summary

This study seeks to determine the levels of indoor ionizing background radiations in quarries, human premises, soil from agricultural zones, and tuber crops (arrowroots, cassava, sweet potato and Irish potato). Calibrated Radiation AlertR(Digilert 200) handheld radiation detectors will be used to capture the readings from quarries and human premises. Gamma spectrometry will be used to record levels of ionizing radiation in water, soils, and tuber crops.


Ndile Michael Musila
PhD ( Medical Biochemistry )
Areas of Interest: Diabetes, phytomedicine, Toxicology, pharmacology and drug discovery.
Email:2mmusila@gmail.com

Project Title: ANTIDIABETIC, ANTIOXIDANT AND SAFETY PROFILE OF DICHLOROMETHANE (DCM) EXTRACTS OF Xerophyta spekei (BAKER) IN STREPTOZOTOCIN-INDUCED DIABETIC SWISS ALBINO MICE

Project Summary

The study focuses on determining bioactive compounds present in Xerophyta spekei, its antidiabetic potential both in vivo and in vitro, possible mechanism of action and its safety in application to complimentary medicine


Juma Kelvin Kisaka
PhD ( Medical Biochemistry )
Areas of Interest: Immunopathology, drug discovery and pharmacotoxicity
Email:juma.kelvin85@gmail.com

Project Title: EFFECTS OF Urtica dioica, Cucurbita pepo and Spinacea oleracea EXTRACTS IN AMELIORATION OF ALCOHOL INDUCED TOXICITY IN RAT MODELS

Project Summary

The study is on the effects of alcohol at both acute and chronic doses and the impact of damage to the kidneys, liver, spleen, pancrease and blood and how they can be managed using bioactive compounds from locally available vegetables and compared to the use of corticosteroids such as prednisolone and a commercially used herbal remedy, Silymarin. The study also explores the immunopathological pathways of cytokines modulations in alcohol induced tissue damage.



Masters Students


DENNIS MWANGANGI MBITI
Masters ( Medical Biochemistry )
Areas of Interest: oncology, drug development, clinical medicine, phytochemistry, medical physiology
Email:dennismwangangi8@gmail.com

Project Title: DETERMINATION OF BACKGROUND IONIZING RADIATION IN QUARRIES, HOUSE PREMISES AND SOIL IN MERU COUNTY

Project Summary

The study entails determining background ionizing radiation in selected quarries, house premises and collected soil samples from Meru County as potential cause of increased cancer cases.


Hezron Mutisya Muindi
Masters ( Medical Biochemistry )
Areas of Interest: Hematology, blood transfusion science, blood coagulation, clinical chemistry, medical physiology, drug development, traditional medicine.
Email:hezronmuindi@gmail.com

Project Title: Relative Astringent and Hemostatic Activities of Methanolic Leaf Extracts of Croton megalocarpus Hutch andLantana camara Linn.

Project Summary

Croton megalocarpus Hutch and Lantana camara Linn plant materials are used in traditional medicine in some communities around the world in the control of peripheral bleeding following traumatic injury. This study seeks to determine the effects of methanolic leaf extracts of C. megalocarpus(H.) and L. camara (L.) on hemoglobin precipitation and activity of extracts from both plants on mice plasma coagulation time.


Dominic Omundi Osoro
Masters ( Medical Biochemistry )
Areas of Interest: Medical Biochemistry and Phytomedicine
Email:osoropius@gmail.com

Project Title: In vivo Ameliorative effects of aqueous leaf extract of Vigna unguiculata in mice following lead and mercury-induced toxicity.

Project Summary

Due to pollution, human beings and animals have been exposed to heavy metals through their diet, medical , occupation and accidental exposure which result into poisoning. To manage this kind of poisoning, use of various plant extracts have been employed, one such plant is Vigna unguiculata. The focus of this study is to determine: the effect of aqueous leaf extract of Vigna unguiculata on the body of mice and its relative organ weight, hematological and biochemical parameters and, its antioxidant effects on mice following lead and mercury induced toxicity. It also seeks to quantitatively determine the phytochemical profile of the aqueous leaf extract of Vigna unguiculata.